منابع مشابه
Loss of Podocyte aPKC / Causes Polarity Defects and Nephrotic Syndrome
Atypical protein kinase C (aPKC) is a central component of the evolutionarily conserved Par3-Par6aPKC complex, one of the fundamental regulators of cell polarity. We recently demonstrated that these proteins interact with Neph-nephrin molecules at the slit diaphragm of the glomerular filtration barrier. Here, we report that podocyte-specific deletion of aPKC / in mice results in severe proteinu...
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Mathematical chemistry is a branch of theoretical chemistry for discussion and prediction of the molecular structure using mathematical methods without necessarily referring to quantum mechanics. In theoretical chemistry, distance-based molecular structure descriptors are used for modeling physical, pharmacologic, biological and other properties of chemical compounds. The Wiener Polarity index ...
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Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganization drives oncogenic transcriptional events remains unclear. The polarity regulators of the Drosophila Scribble (Scrib) module are potent tumor suppressors and provide a model for mechanistic investigation. RNA profiling of Scrib mutant tumors reveals multiple signatures of neoplasia, includi...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2013
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3626